Over the past 6 years, a growing body of research (in animals and people) also supports the effectiveness and safety of injecting the corpus cavernosi of the penis with BOTOX. In the latest randomized, double-blind, placebo-controlled prospective comparative study, the most effective and longest-lasting dose for improvement of erection firmness was 100 units of BOTOX. This dose showed effectiveness up to 6 months with maximal effect at 6 weeks.
The mechanism of action of BOTOX in the penis seems to be partly due to the relaxation of the smooth muscle of the penis, resulting in increased blood flow (and even in a small increase in length in one study). This increase in erection firmness by increasing blood flow is exactly how Viagra and Tri-mix injections work.
BOTOX (at doses much higher than 100 units) has been used for 2 decades for various problems with an extremely safe history.
The toxic LD50 dose for Botox for a 165-pound man is around 133 vials of 100 units each. We only use 1 vial of 100 units to do Bocox™ and P-Shot 100™. (Read, How many bottles of Botox does it take to kill someone” here).
I am now offering the P-Shot® (Priapus Shot®) procedure combined with 100 units of Botox–the combination of the two is called the P-Shot 100™ (Priapus Shot 100™) procedure.
The P-Shot 100™ procedure is a specific method of injecting blood-derived growth factors, including platelet-rich plasma (or PRP) and BOTOX, to improve the health of the penis and enhance the size (up to 1cm increase in length), and improve ED. Most men experience a more pronounced morning erection and better firmness.
Though results may varied, the benefits last from one year to 18 months.
Men with erectile dysfunction, who failed ED medications like Viagra, Cialis.
Suppose someone wants Botox alone injected into the penis. In that case, we have the Bocox ™ (BoPriapus™) procedure: a specific method of injecting the corpus cavernosi of the penis with botulinum neurotoxin (BoNT)–BOTOX– to improve penile tissue health and to enhance erectile function and penis size (improve in length by 1 cm). The benefits will last for 6 months with Botox alone.
Men with erectile dysfunction up to 5 years.
As with all procedures, there can be complications (some unexpected and of unknown severity). Using Botox for ED is an off-label use for BOTOX not approved by the FDA–as are other common “off-label” uses of BOTOX. Some experts do not think Botox should be used for ED. Thankfully, we have 2 decades of use of Botox, with millions of doses per year, for many indications with an extremely high safety profile.
Abdelrahman, Islam Fathy Soliman, Amr Abdel Raheem, Yaser Elkhiat, Abdelrahman A. Aburahma, Tarek Abdel-Raheem, and Hussein Ghanem. “Safety and Efficacy of Botulinum Neurotoxin in the Treatment of Erectile Dysfunction Refractory to Phosphodiesterase Inhibitors: Results of a Randomized Controlled Trial.” Andrology 10, no. 2 (2022): 254–61. https://doi.org/10.1111/andr.13104.
El-Shaer, Waleed, Hussein Ghanem, Tamer Diab, Ahmed Abo-Taleb, and Wael Kandeel. “Intra-Cavernous Injection of BOTOX® (50 and 100 Units) for Treatment of Vasculogenic Erectile Dysfunction: Randomized Controlled Trial.” Andrology 9, no. 4 (2021): 1166–75. https://doi.org/10.1111/andr.13010.
Giuliano, Francois, Charles Joussain, and Pierre Denys. “Safety and Efficacy of Intracavernosal Injections of AbobotulinumtoxinA (Dysport®) as Add-on Therapy to Phosphosdiesterase Type 5 Inhibitors or Prostaglandin E1 for Erectile Dysfunction—Case Studies.” Toxins 11, no. 5 (May 21, 2019): 283. https://doi.org/10.3390/toxins11050283.
Habashy, Engy, and Tobias S. Köhler. “Botox for Erectile Dysfunction.” The Journal of Sexual Medicine 19, no. 7 (July 2022): 1061–63. https://doi.org/10.1016/j.jsxm.2022.03.216.
Naumann, Markus, and Joseph Jankovic. “Safety of Botulinum Toxin Type A: A Systematic Review and Meta-Analysis.” Current Medical Research and Opinion 20, no. 7 (July 2004): 981–90. https://doi.org/10.1185/030079904125003962.